This learning guide, commissioned by the Collaborative Adaptation Research Initiative in Africa and Asia (CARIAA), is designed to provide research teams with a bottom-up and experience based tool to better understand the effectiveness – and inefficiencies – of different approaches to Research-into-Use (RiU), the uptake of research which contributes to a change in policy or practice. The learning approach can also help to facilitate adaptive and reflexive approaches to RiU. Although this guide was developed for CARIAA, it has been designed so that any research programme interested in improving its RiU practices can use it. It also includes a pocket guide for easy use in the field.