Oxfam's humanitarian work aims to have the maximum impact on the health of populations affected by crises through the integration of Oxfam's various sectoral activities.

Oxfam's humanitarian personnel are responsible for a wide range of activities, including advising Oxfam's international regions on humanitarian response, building regional capacity to respond to emergencies, leading programme development work on key areas such as WASH, public health, food security, HIV and AIDS, protection, gender, and preparedness. They also deliver advocacy on humanitarian issues in developed countries and provide security management advice.